John Brendan Guinan is an interdisciplinary artist based in Brooklyn, NY. He employs a diverse range of mediums, including textiles, painting, collage, assemblage, readymades, installation, sculpture, performance, and film. His conceptually driven practice engages with world-building, theology, and ritual as frameworks for exploring systems of belief, meaning, and transformation. Central to his oeuvre is the reconfiguration of materials and objects - integrating religious, quotidian, military, high, and low-brow elements such as bungee cords, church pews, tarps, ratchet straps, firearms, machetes, ecclesiastical vestments, and designer textiles among others. The artist draws from a wide range of influences, including liturgical traditions, religious iconography, mythology, the occult, horror, fashion, cinema, and literature.

Guinan was born at home in the Logan Circle neighborhood of Washington, DC, above the homeless shelter and soup kitchen founded and run by his parents. His upbringing was deeply rooted in the Catholic Worker tradition, emphasizing non-violence, hospitality, and anarchism. His father, J. Edward Guinan (dec. 2014), a former Catholic priest, prominent activist, and author, founded one of the largest homeless shelters in America, the Community for Creative Non-Violence. This heritage, particularly the convergence of theology and activism profoundly shaped the artist's worldview and practice.

Guinan has exhibited at Sotheby's (NY), O'Flaherty's (NY), LatchKey Gallery (NY), Queensway Television (Singapore), Wassaic Project (NY), NYU, Katzen Art Center at American University (DC), Dupont Underground (DC), De Re Gallery (LA), and Bristol Art Museum (RI) among others. He was the 2024 recipient of the Emily Mason & Wolf Kahn Fellowship Award in support of his residency at The Vermont Studio Center and has been selected for the 2025 Rondo Residency in Mexico City. In 2018, the artist was the subject of "Why I Paint," a documentary produced by Emmy and Academy Award-winning Fine Films.